• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Previous Issues
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Egyptian Journal of Histology
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 48 (2025)
Volume Volume 47 (2024)
Volume Volume 46 (2023)
Volume Volume 45 (2022)
Volume Volume 44 (2021)
Volume Volume 43 (2020)
Volume Volume 42 (2019)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 41 (2018)
Volume Volume 40 (2017)
Osman, F., Yacoub, M., Mohammed, S., mogahed, O. (2019). Comparative Histological Study between the Effect of Calcitonin versus Hormonal Replacement Therapy on Cartilage of Knee Joint of Ovariectomized Albino Rat. Egyptian Journal of Histology, 42(3), 515-525. doi: 10.21608/ejh.2019.7235.1068
Faten Riad Osman; Mira Farouk Youssef Yacoub; Samraa Hussein Abdel- Kawi Mohammed; ola esmail mogahed. "Comparative Histological Study between the Effect of Calcitonin versus Hormonal Replacement Therapy on Cartilage of Knee Joint of Ovariectomized Albino Rat". Egyptian Journal of Histology, 42, 3, 2019, 515-525. doi: 10.21608/ejh.2019.7235.1068
Osman, F., Yacoub, M., Mohammed, S., mogahed, O. (2019). 'Comparative Histological Study between the Effect of Calcitonin versus Hormonal Replacement Therapy on Cartilage of Knee Joint of Ovariectomized Albino Rat', Egyptian Journal of Histology, 42(3), pp. 515-525. doi: 10.21608/ejh.2019.7235.1068
Osman, F., Yacoub, M., Mohammed, S., mogahed, O. Comparative Histological Study between the Effect of Calcitonin versus Hormonal Replacement Therapy on Cartilage of Knee Joint of Ovariectomized Albino Rat. Egyptian Journal of Histology, 2019; 42(3): 515-525. doi: 10.21608/ejh.2019.7235.1068

Comparative Histological Study between the Effect of Calcitonin versus Hormonal Replacement Therapy on Cartilage of Knee Joint of Ovariectomized Albino Rat

Article 1, Volume 42, Issue 3, September 2019, Page 515-525  XML PDF (934.64 K)
Document Type: Review Article
DOI: 10.21608/ejh.2019.7235.1068
Cited by Scopus (1)
View on SCiNiTO View on SCiNiTO
Authors
Faten Riad Osman1; Mira Farouk Youssef Yacoub1; Samraa Hussein Abdel- Kawi Mohammed2; ola esmail mogahed email 3
1Department of Histology, Faculty of Medicine, Cairo University
2Department of Histology, Faculty of Medicine, Beni-Suef University
3histology, faculty of medicine, beni-suif
Abstract
Background: Osteoarthritis (OA) is the most common age-related joint degenerative disease, which is associated with post menopausal females.  Aim of Work: To compare the effect of hormonal replacement therapy (HRT) (Oestrogen and Progesterone) versus calcitonin administration on articular cartilage of the knee joints in murine model of osteoarthritis induced by ovariectomy.  Materials and Methods: Thirty six adult female rats were divided into five groups. Group I: control; Group II: sham operated; Group III: ovariectomized rats: Group IV: ovariectomized then received HRT )1ml/kg(0.2ml)/day IM ((for 8 weeks); GroupV: ovariectomized then received calcitonin )2 IU/kg/day (0.04ml) SC( (for 8 weeks). The rats of each group were sacrificed after 8 weeks. Articular cartilage of knee joints were processed and stained with Haematoxylin and Eosin, Alcian blue, PAS, immunohistochemical staining of Bcl-2 and statistical analysis were applied.  Results: Ovariectomy resulted in degeneration, apoptosis and deterioration of normal structure of articular cartilage, with decreased PAS reaction, decreased Alcian blue staining, and weak immunoreactivity for Bcl-2 when compared with the control and sham operated groups. Calcitonin and HRT supplementation after ovariectomy mostly prevented these changes.  Conclusion: It could be concluded that OVX causes severe changes in articular cartilage and these changes are more evident with time. HRT had a significant effect in prevention of cartilage degradation in OVX model of OA. Calcitonin administration greatly improves the histological architecture of the articular cartilage. So calcitonin had a significant effect in prevention of cartilage degradation in OVX model of OA. It can be considered as a potential therapeutic agent in OA.
Keywords
Bcl-2; Calcitonin; cartilage; HRT; osteoarthritis; Ovariectomy
Statistics
Article View: 575
PDF Download: 906
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.