• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Egyptian Journal of Histology
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 45 (2022)
Volume Volume 44 (2021)
Volume Volume 43 (2020)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 42 (2019)
Volume Volume 41 (2018)
Volume Volume 40 (2017)
Abdel-kareem, R., Domouky, A. (2020). Role of Β-Carotene Against Toxic Effect of Titanium Dioxide Nanoparticles on Cerebral Cortex of Adult Albino Rat: Histological and Biochemical Approach. Egyptian Journal of Histology, 43(2), 441-454. doi: 10.21608/ejh.2019.16387.1160
Reham Abdel-kareem; Ayat Domouky. "Role of Β-Carotene Against Toxic Effect of Titanium Dioxide Nanoparticles on Cerebral Cortex of Adult Albino Rat: Histological and Biochemical Approach". Egyptian Journal of Histology, 43, 2, 2020, 441-454. doi: 10.21608/ejh.2019.16387.1160
Abdel-kareem, R., Domouky, A. (2020). 'Role of Β-Carotene Against Toxic Effect of Titanium Dioxide Nanoparticles on Cerebral Cortex of Adult Albino Rat: Histological and Biochemical Approach', Egyptian Journal of Histology, 43(2), pp. 441-454. doi: 10.21608/ejh.2019.16387.1160
Abdel-kareem, R., Domouky, A. Role of Β-Carotene Against Toxic Effect of Titanium Dioxide Nanoparticles on Cerebral Cortex of Adult Albino Rat: Histological and Biochemical Approach. Egyptian Journal of Histology, 2020; 43(2): 441-454. doi: 10.21608/ejh.2019.16387.1160

Role of Β-Carotene Against Toxic Effect of Titanium Dioxide Nanoparticles on Cerebral Cortex of Adult Albino Rat: Histological and Biochemical Approach

Article 6, Volume 43, Issue 2, June 2020, Page 441-454  XML PDF (1.16 MB)
Document Type: Original Article
DOI: 10.21608/ejh.2019.16387.1160
Authors
Reham Abdel-kareemorcid 1; Ayat Domouky email 2
1Anatomy Department, Faculty of Medicine, Zagazig University
2anatomy department, faculty of medicine, zagazig university, zagazig
Abstract
Objective: Detect the neurotoxic effect of titanium dioxide nanoparticles by investigation of the biochemical and histological changes in cerebral cortex of albino rats, and to evaluate the potential protective role of β-carotene against this toxicity.
Methods: Titanium dioxide nanoparticles (TiO2 NPs) administered intraperitoneal 100, 300 mg/kg, daily for 14 days besides one protected group received 10mg/kg β-carotene by gavage for 7 days prior and 14 days with 300 mg/kg nanoparticles administration, along with one control group and one group received 10mg/kg β-carotene by gavage for 21 days. Histological and histochemichal cerebral cortical tissue examination and standard biochemical methods for estimation of enzymes superoxide dismutase, glutathione peroxidase, catalase, alkaline phosphatase, gamma-glutamyl transpeptidase, and 5’ nucleotidase were implemented.
Results: In contrast to administration of low dose TiO2 NPs, administration of high dose TiO2 NPs led to marked histological changes in form of decrease number of vesicular neurons and loss of background homogeneity with appearance of vacuolations and hydropic changes. Moreover, increase in astrocytes number with appearance of area of gliosis and increase in apoptosis index. Biochemical analysis showed significant decreases in the activities of the antioxidant enzymes: superoxide dismutase, glutathione peroxidase and catalase. Besides, significant decrease in the activities of alkaline phosphatase and gamma-glutamyl transpeptidase, although the activity of 5’-nucleotidase was not inclined significantly by administration of nanoparticles. These changes didn’t markedly appear with the use of β-carotene.
Conclusion: High dose TiO2 NPs has neurotoxic effects but application of β-carotene may serve as a beneficial medication to protect against neurotoxicity induced by nanoparticles.
Keywords
β-carotene; apoptosis; biochemical; neurotoxicity; titanium dioxide nanoparticles
Statistics
Article View: 1,767
PDF Download: 174
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.