Sarheed, N., AL-tameemi, H., Imarah, A. (2025). Synergistic Activity of Cisplatin and Anise Extract Nanoparticles to Inhibit the Tumor of Mammary Cancer Cells in Mice. Egyptian Journal of Histology, 48(1), 174-185. doi: 10.21608/ejh.2024.242091.1963
Nael Mohammed Sarheed; Hamid K AL-tameemi; Ameer Ali Imarah. "Synergistic Activity of Cisplatin and Anise Extract Nanoparticles to Inhibit the Tumor of Mammary Cancer Cells in Mice". Egyptian Journal of Histology, 48, 1, 2025, 174-185. doi: 10.21608/ejh.2024.242091.1963
Sarheed, N., AL-tameemi, H., Imarah, A. (2025). 'Synergistic Activity of Cisplatin and Anise Extract Nanoparticles to Inhibit the Tumor of Mammary Cancer Cells in Mice', Egyptian Journal of Histology, 48(1), pp. 174-185. doi: 10.21608/ejh.2024.242091.1963
Sarheed, N., AL-tameemi, H., Imarah, A. Synergistic Activity of Cisplatin and Anise Extract Nanoparticles to Inhibit the Tumor of Mammary Cancer Cells in Mice. Egyptian Journal of Histology, 2025; 48(1): 174-185. doi: 10.21608/ejh.2024.242091.1963
Synergistic Activity of Cisplatin and Anise Extract Nanoparticles to Inhibit the Tumor of Mammary Cancer Cells in Mice
1College of Medicine, Al-Muthanna University, Al-Muthanna-Iraq.
2Diyala University, Faculty of science,Biology department.
3Biology Department-Faculty of Science -kufa University
Abstract
Cancer is a major health problem worldwide and is one of the leading causes of death. Preventing tumor development is a significant challenge due to the similarity in cellular mechanisms between cancerous and normal cells; however, biological substances have high efficiency against cancerous cells and low toxicity against normal cells associated with a good prognosis. Therefore, the current study is designed to study the role of Anise extract (A.E.) and Anise extract- Chitosan nanoparticles in the synergistic effect with Cisplatin in the treatment of tumor-induced in female mice. Materials and methods: Five groups of female mice, six mice for each group, were included to achieve the goal of the present study. These study groups were control, tumor-induced, Cisplatin treated, Cisplatin – Anise extract treated, and Cisplatin- Anise extract- Chitosan nanoparticles treated groups. The tumor size and some biomarkers (IL-33, LRG-1, and CRP) were considered indicators for tumor development and response to the treatment protocol. Results: The present study found that the tumor size in the tumor-induced group reached 33.1 mm after 30 days of inducement, while the tumor size in the treated group was significantly smaller than in the tumor-induced group. The tumor size in the Cisplatin- Anise extract group was smaller than the Cisplatin treated group. Also, the effect of Cisplatin against a tumor increased when combining anise extract with Chitosan nanoparticles. The biomarkers showed that IL-33, LRG-1, and CRP levels were higher in the tumor group than in the control and other study groups. Conclusion: The current study concluded that the anise extract has high effectiveness in reinforcing Cisplatin action against tumor development and, simultaneously, increased their effect by nanoparticles.
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