AL-tameemi, H., Sarheed, N., Imarah, A. (2024). Synergistic activity of cisplatin and anise extract nanoparticles to inhibit the Tumor of mammary cancer cells in mice. Egyptian Journal of Histology, (), -. doi: 10.21608/ejh.2024.242091.1963
Hamid K AL-tameemi; Nael Mohammed Sarheed; Ameer Ali Imarah. "Synergistic activity of cisplatin and anise extract nanoparticles to inhibit the Tumor of mammary cancer cells in mice". Egyptian Journal of Histology, , , 2024, -. doi: 10.21608/ejh.2024.242091.1963
AL-tameemi, H., Sarheed, N., Imarah, A. (2024). 'Synergistic activity of cisplatin and anise extract nanoparticles to inhibit the Tumor of mammary cancer cells in mice', Egyptian Journal of Histology, (), pp. -. doi: 10.21608/ejh.2024.242091.1963
AL-tameemi, H., Sarheed, N., Imarah, A. Synergistic activity of cisplatin and anise extract nanoparticles to inhibit the Tumor of mammary cancer cells in mice. Egyptian Journal of Histology, 2024; (): -. doi: 10.21608/ejh.2024.242091.1963
Synergistic activity of cisplatin and anise extract nanoparticles to inhibit the Tumor of mammary cancer cells in mice
Articles in Press, Accepted Manuscript, Available Online from 16 January 2024
1Diyala University, Faculty of science,Biology department.
2College of Medicine, Al-Muthanna University, Al-Muthanna-Iraq.
3Biology Department-Faculty of Science -kufa University
Abstract
Cancer is a major health problem worldwide and is one of the leading causes of death. Preventing tumor development is a significant challenge due to the similarity in cellular mechanisms between cancerous and normal cells; however, biological substances have high efficiency against cancerous cells and low toxicity against normal cells associated with a good prognosis. Therefore, the current study is designed to study the role of Anise extract (A.E.) and Anise extract- Chitosan nanoparticles in the synergistic effect with Cisplatin in the treatment of tumor-induced in female mice. Materials and methods: Five groups of female mice, six mice for each group, were included to achieve the goal of the present study. These study groups were control, tumor-induced, Cisplatin treated, Cisplatin – Anise extract treated, and Cisplatin- Anise extract- Chitosan nanoparticles treated groups. The tumor size and some biomarkers (IL-33, LRG-1, and CRP) were considered indicators for tumor development and response to the treatment protocol. Results: The present study found that the tumor size in the tumor-induced group reached 33.1 mm after 30 days of inducement, while the tumor size in the treated group was significantly smaller than in the tumor-induced group. The tumor size in the Cisplatin- Anise extract group was smaller than the Cisplatin treated group. Also, the effect of Cisplatin against a tumor increased when combining anise extract with Chitosan nanoparticles. The biomarkers showed that IL-33, LRG-1, and CRP levels were higher in the tumor group than in the control and other study groups. Conclusion: The current study concluded that the anise extract has high effectiveness in reinforcing Cisplatin action against tumor development and, simultaneously, increased their effect by nanoparticles.