Sadek, M., Aboraya, A., laag, E., Khallaf, Y. (2023). Comparative Histological Study on the Protective and Therapeutic Role of Açai Berry Extract on Experimentally Induced Fundic Gastric Mucosal Injury in Adult Male Albino Rat. Egyptian Journal of Histology, (), -. doi: 10.21608/ejh.2023.223050.1921
Mona Tayssir Sadek; Azza Aboraya; essam mahmoud laag; Yassmin T Khallaf. "Comparative Histological Study on the Protective and Therapeutic Role of Açai Berry Extract on Experimentally Induced Fundic Gastric Mucosal Injury in Adult Male Albino Rat". Egyptian Journal of Histology, , , 2023, -. doi: 10.21608/ejh.2023.223050.1921
Sadek, M., Aboraya, A., laag, E., Khallaf, Y. (2023). 'Comparative Histological Study on the Protective and Therapeutic Role of Açai Berry Extract on Experimentally Induced Fundic Gastric Mucosal Injury in Adult Male Albino Rat', Egyptian Journal of Histology, (), pp. -. doi: 10.21608/ejh.2023.223050.1921
Sadek, M., Aboraya, A., laag, E., Khallaf, Y. Comparative Histological Study on the Protective and Therapeutic Role of Açai Berry Extract on Experimentally Induced Fundic Gastric Mucosal Injury in Adult Male Albino Rat. Egyptian Journal of Histology, 2023; (): -. doi: 10.21608/ejh.2023.223050.1921
Comparative Histological Study on the Protective and Therapeutic Role of Açai Berry Extract on Experimentally Induced Fundic Gastric Mucosal Injury in Adult Male Albino Rat
Articles in Press, Accepted Manuscript, Available Online from 20 September 2023
1Histology department, Faculty of medicine, Tanta University
2Histology Department, Tanta Faculty of Medicine, Tanta, Egypt
3Histology Department, Faculty of Medicine, Tanta University, Egypt
Abstract
Introduction: Gastric injury is considered a common global medical problem with different etiology. Açai berry, a fruit rich in antioxidant and anti-inflammatory compounds, is lately considered a promising protective and therapeutic agent. Aim of the work: To assess the probable protective and therapeutic effects of açai berry extract on gastric fundic mucosal injury, experimentally induced by NSAIDs. Materials & Methods: 50 adult male albino rats were equally distributed into 5 groups; I (control), II (açai berry extract) that received the extract orally (300 mg/kg) once per day for 14 days, III (injury) which received one dose of diclofenac sodium (100 mg/kg) orally, IV (protected) that received the extract for 14 days then one dose of diclofenac sodium and V (treated) that was given diclofenac sodium once then given the extract for 14 days. The fundic specimens were examined by light microscopy (H&E, PAS, caspase-3, PCNA) and scanning electron microscopy (SEM). Results: Group III showed sloughed mucosal surface cells, areas of mucosal discontinuity, cytoplasmic vacuolation, inflammatory cellular infiltration and congested blood vessels. Absent PAS-reactivity and strong caspase-3 immunoreaction together with decreased PCNA immunoreaction were also reported. SEM revealed loss of the surface mucosal cells with honeycomb appearance besides presence of rough surface and cavitation of some surface cells. Wide gastric pits and deep craters were observed. Group IV exhibited preserved normal histological structure of the fundic mucosa. Group V revealed improvement of the histological changes reported in group III. Conclusion: Açai berry extract has promising effects in both protection against and treatment of fundic gastric injury due to NSAIDs, however these effects were more prominent in the protection over the treatment.