Essawy, A., Issa, N., Tayel, S. (2022). Glycyrrhiza Glabra Root Extract Alleviates Cyclophosphamide Induced Mucositis of the Tongue in Adult Male Albino Rats. Egyptian Journal of Histology, 45(4), 1222-1234. doi: 10.21608/ejh.2021.81575.1510
Asmaa Saeed Essawy; Noha mohey Issa; sara gamal Tayel. "Glycyrrhiza Glabra Root Extract Alleviates Cyclophosphamide Induced Mucositis of the Tongue in Adult Male Albino Rats". Egyptian Journal of Histology, 45, 4, 2022, 1222-1234. doi: 10.21608/ejh.2021.81575.1510
Essawy, A., Issa, N., Tayel, S. (2022). 'Glycyrrhiza Glabra Root Extract Alleviates Cyclophosphamide Induced Mucositis of the Tongue in Adult Male Albino Rats', Egyptian Journal of Histology, 45(4), pp. 1222-1234. doi: 10.21608/ejh.2021.81575.1510
Essawy, A., Issa, N., Tayel, S. Glycyrrhiza Glabra Root Extract Alleviates Cyclophosphamide Induced Mucositis of the Tongue in Adult Male Albino Rats. Egyptian Journal of Histology, 2022; 45(4): 1222-1234. doi: 10.21608/ejh.2021.81575.1510
Glycyrrhiza Glabra Root Extract Alleviates Cyclophosphamide Induced Mucositis of the Tongue in Adult Male Albino Rats
1Human Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Anatomy Department, Ibn Sina National College for medical Studies, Jeddah, Saudi Arabia
2anatomy,faculty of medicine,Menofia university,shebin el_kom,Egypt
3anatomy, faculty of medicine , menoufia university
Abstract
Introduction: Cyclophosphamide (CPA) is an anti-cancer medication, utilized in chemotherapy. Recently, inflammation of oral mucosa (mucositis) is thought to be one of the most serious side effects of anticancer therapy. Aim of the Work: To investigate the role of glycyrrhiza glabra (Licorice) root extract on rat tongue mucositis induced by CPA. Materials and Methods: Forty adult male albino rats were classified into four groups, (each included 10 rats): Group I (Control group), Group II (Licorice group): each rat received licorice root extract by an oral daily dose of 200 mg/kg/day for 10 days, Group III (CPA group): each rat received CPA in a single intraperitoneal dose of 300 mg/kg on the second day of experiment and Group IV (Licorice CPA group): each rat received licorice root extract by an oral daily dose of 200 mg/kg/day for ten days, on the second day of experiment, the rats received CPA in a single intraperitoneal dose of 300 mg/kg. At the end of the experiment, the rats were anesthetized, and the tongue was excised for histological, immunohistochemical and ultrastructural analysis. Morphometric and statistical analysis were also done. Results: Licorice root extract reduced the severity of CPA induced oral mucositis by increasing the epithelial thickness, normalization of congested blood vessels in the lamina propria of tongue mucosa, significant amelioration of immunoreactivity to anti-Ki-67, anti-E-cadherin and anti-P53. Conclusion: CPA chemotherapy has a detrimental effect on the oral mucosa resulting in marked morphometric and microscopic changes. Glycyrrhiza glabra extract can protect the oral mucosa from CPA-induced toxicity and reduce the associated injuryز
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