Effect of Different Doses of Energy Drink on The Pancreas of Adult Male Albino Rats and The Effects of Its Withdrawal. Light and Electron Microscopic Study

Document Type : Original Article

Authors

1 Histology department, Faculty of medicine Ain shams university

2 Youssif Abbas

3 Histology department Faculty of medicine Ain shams university

4 Histology and cell biology, faculty of medicine, ain shams university

Abstract

Introduction: Energy drinks are non-alcoholic beverages containing mainly caffeine which recently became frequently used as concentrate boosting agents. Recent findings indicate that caffeinated energy drinks can affect the structure and function of many organs.
Aim of the Work: Studying the influence of different doses of Red Bull -as an example of caffeinated energy drinks- on the pancreas of adult male albino rats and the effects of its withdrawal using microscopic techniques.
Materials and Methods: 63 adult male albino rats were separated into three groups. Group I (control group), Group II (energy drink administered) was divided into IIA and IIB that were orally administrated Red Bull 7.5 ml/kg/day and 15 ml/kg/day respectively once daily for 4 weeks, and Group III (energy drink withdrawal) was divided into IIIA and IIIB that were administrated Red Bull as IIA and IIB respectively, then were left for 15 days without any treatment. Light and transmission electron microscopic studies were performed.
Results: Red Bull administration demonstrated focally disrupted architecture in both the exocrine and endocrine pancreas.These changes were dose dependent, as they were more noticeable and extended to include wide areas of pancreatic lobules in the subgroup administered high dose energy drink. Discontinuing the intake of Red Bull partially improved these alterations particularly in the low dose subgroup.
Conclusion: Consumption of energy drinks caused dose-dependent histological changes in the pancreas structure, and its withdrawal partially improved these alterations, particularly in rats administered lower consumption.

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