Role of Alpha-lipoic acid and Naringin in Modulating Bisphenol-A Induced Perturbations of Prostate in Adult Rats (Histological and Immunohistochemical Study)

Document Type : Original Article

Authors

1 Department of Human Anatomy and Embryology Faculty of medicine, Suez Canal University.

2 Department of Human Anatomy and Embryology Faculty of medicine, Suez Canal University

3 Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Abstract

Introduction: Bisphenol-A is categorized as an endocrine disruptor. A biological thiol antioxidant that lowers oxidative damage is alpha-lipoic acid. Flavone naringin has antioxidant properties.
Aim of the Work: To evaluate the ability of α-Lipoic Acid and Naringin to ameliorate disruptive effects of BPA on the prostate gland in adult rats.
Materials and Methods: Seventy-two adult rats were divided randomly into nine groups. Group I: (IA, IB and group IC). Group II: BPA, group III: BPA+α-LA, group IV: BPA+N, group V: BPA+α-LA+N, group VI: α-LA group, and group VII: N. After 30 days, the rats were sacrificed and evaluation of blood T, E2, weight gain, prostate volume, weight, index, and ventral lobe weight were done. The ventral lobes of Prostate were handled for the histological, immunohistochemical and morphometric analyses.
Results: Bisphenol-A significantly reduced serum T and E2 levels, decreased the weight gain, increased the prostatic volume, prostatic weight, and the prostatic index. It induced histopathological alterations of the ventral lobe of the prostate by histological and immunohistochemical studies. These changes were also confirmed by the morphometric assessment of the prostate tissue. Alpha-lipoic acid exhibited mild improvement in all parameters. Naringin had a moderate improvement in the parameters disrupted by the BPA. The combination of the α-LA and the N showed synergistic effects compared to the BPA+α-LA and the BPA+N groups. It showed marked improvement in all parameters to be near to normal.
Conclusion: Both Naringin and Alpha-lipoic acid have the potential to be effective protective agents against reproductive toxicity caused by endocrine disruptors.

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