The Potential Ameliorative Impact of Platelet Rich Plasma on Thioacetamide-Induced Liver Fibrosis in Albino Rats: Histomorphometric and Biochemical Study

Document Type : Original Article

Authors

1 Histology and Cell Biology Department. Alexandria Faculty of Medicine, Egypt

2 Histology and Cell Biology Department, Alexandria Faculty of Medicine, Egypt

Abstract

Background: Worldwide liver diseases are considered one of the greatest causes of death. Liver fibrosis resulting from liver injuries, if not treated, leads to liver cirrhosis. Cirrhosis may result in liver dysfunction, portal hypertension, or hepatocellular carcinoma. Thioacetamide (TAA) is a hepatotoxic drug that is applied for the induction of liver fibrosis resembling that occurs in humans. Application of Platelet-rich plasma (PRP) in managing many diseases is presently an area of great scientific interest. Being rich in platelets, secretory proteins and growth factors might promote the healing activity in case of liver fibrosis.

Aim of the work: Examining the potential ameliorative impact of PRP on TAA induced hepatic fibrosis in male adult albino rat model.

Materials and methods: 44 male adult albino rats were distributed into four groups; the control group; received intraperitoneal (i.p) saline twice weekly. The (PRP) group; received i.p PRP twice weekly. The (TAA) group; received i.p TAA twice weekly. The (TAA+PRP) group; received i.p of TA twice weekly, in addition to PRP starting from 4th week of TAA administration until the end of the experiment. All treatments were given for 7 weeks. After 24 hours of the last injection of TAA and PRP, animals were sacrificed. Samples were obtained for biochemical and histomorphometric studies.

Results: The TAA group revealed histological results of liver fibrosis. Administration of PRP showed a marked improvement in the liver architecture and the biochemical results.

Conclusion: PRP reversed hepatocellular damage and fibrosis in addition to the improvement of the liver function tests.

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