Agaga, R., Elsammak, G., amer, N. (2024). Effect of Electronic Cigarette Exposure on The Adrenal Cortex of Adult Male Albino Rats and the Possible Effect of its Withdrawal (Histological and Immunohistochemical Study). Egyptian Journal of Histology, 47(1), 295-310. doi: 10.21608/ejh.2023.176477.1823
Rasha Ahmed Agaga; Ghada Abdelaziz Elsammak; Nehal ahmed amer. "Effect of Electronic Cigarette Exposure on The Adrenal Cortex of Adult Male Albino Rats and the Possible Effect of its Withdrawal (Histological and Immunohistochemical Study)". Egyptian Journal of Histology, 47, 1, 2024, 295-310. doi: 10.21608/ejh.2023.176477.1823
Agaga, R., Elsammak, G., amer, N. (2024). 'Effect of Electronic Cigarette Exposure on The Adrenal Cortex of Adult Male Albino Rats and the Possible Effect of its Withdrawal (Histological and Immunohistochemical Study)', Egyptian Journal of Histology, 47(1), pp. 295-310. doi: 10.21608/ejh.2023.176477.1823
Agaga, R., Elsammak, G., amer, N. Effect of Electronic Cigarette Exposure on The Adrenal Cortex of Adult Male Albino Rats and the Possible Effect of its Withdrawal (Histological and Immunohistochemical Study). Egyptian Journal of Histology, 2024; 47(1): 295-310. doi: 10.21608/ejh.2023.176477.1823
Effect of Electronic Cigarette Exposure on The Adrenal Cortex of Adult Male Albino Rats and the Possible Effect of its Withdrawal (Histological and Immunohistochemical Study)
1Anatomy department faculty of medicine zagazig university , zagazig
2Department of Histology and cell biology, Faculty of medicine, Zagazig university.
Abstract
Introduction: Electronic cigarettes, also known as "cigs," are gadgets created to provide nicotine through a vaping solution rather than smoke and without the burning of tobacco. E-cigarettes are aggressively promoted as consumables among people who want to live healthier lives and are seen as a safer alternative to cigarettes. Aim of the Work: To assess structural changes in the adrenal cortex of adult male albino rats and explore effect of withdrawal of electronic cigarette. Material and Methods: 30 adult male rats weighting 150-230 g which were purchased from the Animal house of the faculty of medicine, Zagazig University. The animals will be divided equally into 3groups. Each one contains 10 rats as follows: Group (1): (control group); which contain ten rats that will be exposed to fresh air for 28 days to measure normal basic parameters. Group (II): (E- cig treated group); which contain ten rats that will be exposed to 1ml/day of E- liquid containing 18 mg/ml Nicotine For consecutive 5 days/ week for 28 days. Group (III): (withdrawal group); which contain ten rats which will be exposed to 1ml/day of E- liquid containing 18 mg/ml Nicotine For 5 consecutive days/ week for 4 weeks and then will be left without exposure for another 4 weeks. Results: E-cigarette has hazardous effects on adrenal gland cortex histological structure. Also, there were significant increase in adrenal gland weight and the three zones thickness with elevation of MDA level & reduction of SOD level and also increased the level of cortisol and aldosterone in the group treated with E-cig. Moreover, Caspase 3, COX II immune-expression percent area and the number of CD44 +ve cells were significantly increased in treated group. Conclusion: Exposure of adult male albino rats to E-cigs caused histopathological alterations in the adrenal cortex structure with great improvement in its histological structure and biochemical activity after its withdrawal.
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