Ibrahim, N., Hassan, A., ragab, W., Morsi, E., Elsayed, A. (2022). A Comparative Study on the Effect of Two Topical Formulations of Bee Propolis Cream in Ordinary and Nano Form on Wound Healing in Aged Rats (A Histological and Immunohistochemical Study). Egyptian Journal of Histology, (), -. doi: 10.21608/ejh.2022.154572.1747
Noha Ibrahim; Aliaa Hassan; Waleed ragab; Enas Morsi; Asmaa Elsayed. "A Comparative Study on the Effect of Two Topical Formulations of Bee Propolis Cream in Ordinary and Nano Form on Wound Healing in Aged Rats (A Histological and Immunohistochemical Study)". Egyptian Journal of Histology, , , 2022, -. doi: 10.21608/ejh.2022.154572.1747
Ibrahim, N., Hassan, A., ragab, W., Morsi, E., Elsayed, A. (2022). 'A Comparative Study on the Effect of Two Topical Formulations of Bee Propolis Cream in Ordinary and Nano Form on Wound Healing in Aged Rats (A Histological and Immunohistochemical Study)', Egyptian Journal of Histology, (), pp. -. doi: 10.21608/ejh.2022.154572.1747
Ibrahim, N., Hassan, A., ragab, W., Morsi, E., Elsayed, A. A Comparative Study on the Effect of Two Topical Formulations of Bee Propolis Cream in Ordinary and Nano Form on Wound Healing in Aged Rats (A Histological and Immunohistochemical Study). Egyptian Journal of Histology, 2022; (): -. doi: 10.21608/ejh.2022.154572.1747
A Comparative Study on the Effect of Two Topical Formulations of Bee Propolis Cream in Ordinary and Nano Form on Wound Healing in Aged Rats (A Histological and Immunohistochemical Study)
Articles in Press, Accepted Manuscript, Available Online from 10 December 2022
158 مکرر مريوطيه فيصل امام کوبرى الشيشينى الدور ١٢
22. Biochemistry Department, National Organization for Drug Control & Research, Giza, Egypt
33. Anatomy and Embryology Department, Faculty of Medicine, Fayoum University, Egypt
45. Forensic and Toxicology Department, Faculty of Medicine, Fayoum University, Egypt
51. Histology and cell Biology Department, Faculty of Medicine, Fayoum University, Egypt
Abstract
Background: Aging could result in delayed wound healing. propolis has good effect on healing. Objectives: This investigation was done to assess whether propolis and nanopropolis creams could aid in the healing of wounds in aged rats. Materials and methods: Fifty old-aged albino rats have been separated into four groups: group I (control intact skin) (5 rats); wounded groups: group II (control wounded) (3 subgroups, 5 rats each); subgroup IIa: had vehicle cream once per day for 7 days; subgroup IIb: had vehicle cream once per day for 14 days; and subgroup IIc: had vehicle cream once per day for 21 days; group III (propolis group), which has been divided into 3 subgroups with 5 rats each, received propolis cream once per day for 7 days (subgroup IIIa); once per day for 14 days (subgroup IIIb); and once per day for 21 days (subgroup IIIc), group IV (nanopropolis group), which has been divided into 3 subgroups with 5 rats each, and treatment were topically applied for the same durations as the aforementioned in group III. Hematoxylin and eosin stain, picro sirius red histochemical reaction, and CD 105 immunostain were used in this study. Results: Wound healing was significantly improved in the propolis and nanopropolis groups, with a significant increase in the rate of wound closure and collagen deposition. Conclusion: the current study results confirmed the importance of CD105 in the process of wound healing. Additionally, it demonstrated how effectively propolis and nanopropolis formulas treated aged wounds. This technique might be effective for treating chronic wounds safely and efficiently.