Haq, M., Ali, S., yousaf, M. (2022). LYCOPENE AMELIORATES OVARIAN FOLLICULAR MATURATION IN RAT MODEL OF POLYCYSTIC OVARIAN SYNDROME: A HISTOMORPHOLOGICAL AND FUNCTIONAL STUDY. Egyptian Journal of Histology, (), -. doi: 10.21608/ejh.2022.167869.1788
Minahil Haq; Shabana Ali; Maria yousaf. "LYCOPENE AMELIORATES OVARIAN FOLLICULAR MATURATION IN RAT MODEL OF POLYCYSTIC OVARIAN SYNDROME: A HISTOMORPHOLOGICAL AND FUNCTIONAL STUDY". Egyptian Journal of Histology, , , 2022, -. doi: 10.21608/ejh.2022.167869.1788
Haq, M., Ali, S., yousaf, M. (2022). 'LYCOPENE AMELIORATES OVARIAN FOLLICULAR MATURATION IN RAT MODEL OF POLYCYSTIC OVARIAN SYNDROME: A HISTOMORPHOLOGICAL AND FUNCTIONAL STUDY', Egyptian Journal of Histology, (), pp. -. doi: 10.21608/ejh.2022.167869.1788
Haq, M., Ali, S., yousaf, M. LYCOPENE AMELIORATES OVARIAN FOLLICULAR MATURATION IN RAT MODEL OF POLYCYSTIC OVARIAN SYNDROME: A HISTOMORPHOLOGICAL AND FUNCTIONAL STUDY. Egyptian Journal of Histology, 2022; (): -. doi: 10.21608/ejh.2022.167869.1788
LYCOPENE AMELIORATES OVARIAN FOLLICULAR MATURATION IN RAT MODEL OF POLYCYSTIC OVARIAN SYNDROME: A HISTOMORPHOLOGICAL AND FUNCTIONAL STUDY
Articles in Press, Accepted Manuscript, Available Online from 15 November 2022
2Riphah International Islamic University islamabad
3Riphah international Islamic University Islamabad
Abstract
Abstract Background and aims: Polycystic ovarian syndrome is a menacing metabolic condition with high prevalence rate in Asian countries involving women of reproductive age. This study was commenced to asses favorable effects of lycopene—a dietary component in letrozole induced PCOS rat model. Methods: Fifty adult female Sprague Dawley rats were divided into five groups, ten rats each for a study of 5weeks. Control group A was given standard rat diet. Rats of experimental group B were given 1mg/kg of letrozole to induce PCO model. Group C was given 1mg/kg of letrozole+15mg/kg/day of lycopene. Group D was given 1mg/kg of letrozole+ 500 mg/kg/day metformin. Group E was given 1mg/kg of letrozole +combination of lycopene and metformin together. Relative body weight was taken on day1 and end of experiment. Antioxidant activity was tested using CAT, SOD and MDA . Ovaries were removed for H&E staining and studied under light microscopy. Statical analysis was carried out for result interpretations.
Results: The results showed, restoration of rat weight back to normal by use of lycopene. Histological architecture of ovary showed better count of secondary and graafian follicles towards normal values which was quite reduced in group B proved by significant p-value