Ahmed, S., Mohammed, M., Mahmoud, A. (2018). The role of gold nanoparticles on taxol-induced renal cortex damage in adult male albino rats. Egyptian Journal of Histology, 41(3), 237-249. doi: 10.21608/EJH.2019.25412
Samah M. Ahmed; Maha Z. Mohammed; Abeer A. Mahmoud. "The role of gold nanoparticles on taxol-induced renal cortex damage in adult male albino rats". Egyptian Journal of Histology, 41, 3, 2018, 237-249. doi: 10.21608/EJH.2019.25412
Ahmed, S., Mohammed, M., Mahmoud, A. (2018). 'The role of gold nanoparticles on taxol-induced renal cortex damage in adult male albino rats', Egyptian Journal of Histology, 41(3), pp. 237-249. doi: 10.21608/EJH.2019.25412
Ahmed, S., Mohammed, M., Mahmoud, A. The role of gold nanoparticles on taxol-induced renal cortex damage in adult male albino rats. Egyptian Journal of Histology, 2018; 41(3): 237-249. doi: 10.21608/EJH.2019.25412
The role of gold nanoparticles on taxol-induced renal cortex damage in adult male albino rats
Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abstract
ABSTRACT Introduction: Taxol is a chemotherapeutic drug widely used in the treatment of various types of cancer. Nephrotoxicity is the most hazardous effect complicating chemotherapy. Aim of the work: This research aimed to evaluate the effect of gold nanoparticles on taxol induced nephrotoxicity. Materials and Methods: Thirty adult Wistar male albino rats were divided into three equal groups: the control group (group I) this group was equally subdivided into two subgroups. Taxol-treated group (group II) and gold nanoparticles (GNP)- treated group (group III). Rats in group II received 0.6 mg/ kg body weight Taxol intraperitoneally as a single dose. Animals of group III received Taxol as Group II and after 48 hours, GNPs (400 μg/kg body weight) was administered intravenously via the tail vein daily for 14 days. Kidney function tests were studied. kidney sections were stained with Hematoxylin and Eosin (H&E), Mallory trichrome stain, periodic acid schiff (PAS) reaction and immunohistochemical analysis for inducible nitric oxide synthase (iNOs). Results: Taxol-treated group showed congested glomerular capillaries, cellular infiltration, extravasation and vacuolated tubular cells. Fibrosis in the interstitium was noticed by Mallory trichrome. PAS stained sections showed weak reaction at the brush border of tubular cells. Strong positive reaction for iNOs in the cytoplasm of tubular cells was also noticed. All these changes were improved in GNP-treated group. Conclusion: From the present study, the gold nanoparticles application is promising in the treatment of taxol nephrotoxicity.
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