Hamza, A., Obeid, R., Awwad, R., Kashkoush, D. (2023). Comparative study on the Effect of Platelet Rich Plasma Versus Propolis on Induced Labial Ulcer in Albino Rats. Egyptian Journal of Histology, 46(4), 1752-1762. doi: 10.21608/ejh.2022.149652.1721
Asmaa Khairy Hamza; Raneem F. Obeid; Rania Ahmed Awwad; Dina Kashkoush. "Comparative study on the Effect of Platelet Rich Plasma Versus Propolis on Induced Labial Ulcer in Albino Rats". Egyptian Journal of Histology, 46, 4, 2023, 1752-1762. doi: 10.21608/ejh.2022.149652.1721
Hamza, A., Obeid, R., Awwad, R., Kashkoush, D. (2023). 'Comparative study on the Effect of Platelet Rich Plasma Versus Propolis on Induced Labial Ulcer in Albino Rats', Egyptian Journal of Histology, 46(4), pp. 1752-1762. doi: 10.21608/ejh.2022.149652.1721
Hamza, A., Obeid, R., Awwad, R., Kashkoush, D. Comparative study on the Effect of Platelet Rich Plasma Versus Propolis on Induced Labial Ulcer in Albino Rats. Egyptian Journal of Histology, 2023; 46(4): 1752-1762. doi: 10.21608/ejh.2022.149652.1721
Comparative study on the Effect of Platelet Rich Plasma Versus Propolis on Induced Labial Ulcer in Albino Rats
1Oral biology department, faculty of dentistry, Russian university, Badr city.
2Oral Biology Department, Faculty of Oral and Dental Medicine. Future University in Egypt
3Oral Biology Department, Faculty of Dentistry, Ain Shams University
4Oral Biology Department, Faculty of Dentistry, Ain-Shams University, El-Qobba Bridge, Al Waili, 11566, Cairo, Egypt.
Abstract
Introduction: Oral Mucositis is a multi-etiological inflammatory condition affecting patient’s quality of life. Objectives: The current study aims to evaluate the effect of both Platelet rich plasma (PRP) and Propolis on chemically induced labial mucosal ulcer in albino rats. Material and Methods: 35 adult male albino rats weighing around 200-250 grams were subjected to chemical ulcer induction. Rats were divided into 4 main groups. Group I (negative control): rats did not receive any treatment. Group II in which ulceration was induced in the labial mucosa and left untreated to heal spontaneously. Group III (PRP): in which ulceration was treated by PRP. Group IV (Propolis): in which ulceration was treated by propolis. Each group was further subdivided into 2 equal subgroups A and B in which rats were sacrificed at 5&10 days following ulcer induction respectively. Labial mucosa were dissected and examined histologically and immunohistochemically. Results: Histologically, group I showed normal findings of keratinized stratified squamous epithelium. Group II showed complete epithelial degeneration at day 5, re-epithelialization at day 10. Group III showed beginning of re-epithelization at day 5 and continuous epithelial lining at day 10. Group IV showed apparently moderate thickness of epithelium at day 5 and complete regeneration at day 10. Immunohistochemically and statistically, group IV showed highest immunopositive PCNA expression of epithelial cells followed by group III then group I then group II showed the lowest mean. Conclusions: PRP and Propolis showed vast accelerating effects in healing of chemically-induced ulcers through increased vascularity and enhancing re-epithelization due to their anti-inflammatory and anti-oxidant potentials. Propolis proved to have superior effects compared to PRP
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