The possible ameliorating role of Aloe vera gel on the toxic Effect of Acrylamide on the jejunum of Female albino rats (Light and Scanning Electron Microscopic study)

Introduction: Acrylamide, an industrial chemical found in many industrial applications as well as for chemical and environmental purposes. The Aloe vera plant Known for many years and was known and used for its health, beauty, medicinal and skin care properties. The name Aloe vera derives from the Arabic word “Alloeh” meaning “shining bitter substance,” while “vera” in Latin means “true.” 2000 years ago.
Objective: The aim of the study was to evaluate the role of the Aloe vera extract and its influence on experimental lesions in the jujenal mucosa caused by Acrylamide.
Materials and Method: Thirty adult female albino rats were used and divided equally into three groups (10 rat/eachgroup): (I)control group. (II)Acrylamide treated group (5 mg/kg/day). (III) Acrylamide&Aloe vera treatedgroup (0.4 ml/100g).The experiment extended for 3 weeks, thejejunum samples were collected, prepared and studded by light microscope and scanning electron microscope.
Results: This study revealed that acrylamide administration to rats induces pathological changes in the jejunum in the form of the fused villi;irregular mucosal folds; cellular infiltration and thickened discontinued muscularis externa, with electron microscopic study there were areas of erosion and ulceration of the villi with loss of the normal picture. Administration of Aloe vera gel restored the normal architecture of the villi and crypts with normal appearance of most layers, scanning electron microscopy showed intact epithelium withgoblet cells openings discharging mucus.
Conclusion: Acrylamide markedly affect the jujenal mucosa as seen by light and electron microscope, Aloe vera gel administration can protect the mucosa from this harmful effect