Home Articles List Article Information
Egyptian Journal of Histology
Journal Archive
Volume Volume 48 (2025)
Volume Volume 47 (2024)
Volume Volume 46 (2023)
Volume Volume 45 (2022)
Volume Volume 44 (2021)
Volume Volume 43 (2020)
Volume Volume 42 (2019)
Volume Volume 41 (2018)
Volume Volume 40 (2017)
Mousa, A., El-Mahalaway, A., El-Desoky, R. (2018). The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: A histological and immunohistochemical study. Egyptian Journal of Histology, 41(2), 140-149. doi: 10.21608/EJH.2018.13835
Ayman M. Mousa; Abeer M. El-Mahalaway; Rania E. El-Desoky. "The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: A histological and immunohistochemical study". Egyptian Journal of Histology, 41, 2, 2018, 140-149. doi: 10.21608/EJH.2018.13835
Mousa, A., El-Mahalaway, A., El-Desoky, R. (2018). 'The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: A histological and immunohistochemical study', Egyptian Journal of Histology, 41(2), pp. 140-149. doi: 10.21608/EJH.2018.13835
Mousa, A., El-Mahalaway, A., El-Desoky, R. The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: A histological and immunohistochemical study. Egyptian Journal of Histology, 2018; 41(2): 140-149. doi: 10.21608/EJH.2018.13835

The protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits: A histological and immunohistochemical study

Article 2, Volume 41, Issue 2, June 2018, Page 140-149  XML PDF (1.53 MB)
Document Type: Original Article
DOI: 10.21608/EJH.2018.13835
Cited by Scopus (12)
View on SCiNiTO View on SCiNiTO
Authors
Ayman M. Mousa email 1; Abeer M. El-Mahalaway2; Rania E. El-Desoky2
1Department of Histology and Cell Biology, Faculty of Medicine, Banha University, Banha, Egypt. / Department of Basic health Sciences, CAMS, Qassim University, Kingdom of Saudi Arabia.
2Department of Histology and Cell Biology, Faculty of Medicine, Banha University, Banha, Egypt.
Abstract
Introduction: Chlorinated-water-induced corneal wounds lead to reduced transparency and disability of the cornea. Sodium hyaluronate (SH) is a natural lubricant with unique hygroscopic properties that control tissue hydration for topical eye care with excellent use as an ophthalmic product.
Aim of the work: To evaluate the protective effects of sodium hyaluronate on corneal injuries induced by chlorinated water in adult male rabbits.
Materials and Methods: A total of 20 adult male rabbits were divided equally into four groups treated with 2 drops of sodium hyaluronate on the corneal surface of both eyes two times daily for one month as follow: Group I (G1) was control group treated with distilled water, group II (G2) treated with chlorinated water, group III (G3) treated with SH while, group IV (G4) was treated with 2 drops of SH then 2 drops of chlorinated water. The corneas were excised and processed for histological and immunohistochemical study.
Results: G2 showed epithelial thinning with some areas of cellular ulceration. Disturbance of normal stromal architecture, wide separation of collagen fibers and few degenerated keratocytes were noticed. In addition, a significant decrease of BCL-2 immunoexpression was observed in the cytoplasm of corneal epithelial cells (P<0.01). G3 and G4 showed improvement in the histological and immunohistochemical changes described in G2.
Conclusion: Chlorinated water was harmful to the cornea and SH eye drops proved to minimize these corneal complications. Therefore, application of SH eye drops before swimming is recommended to flush chlorine drops away and to allow the tear film to remain over the cornea.
Keywords
Chlorine; cornea; sodium hyaluronate
Statistics
Article View: 734
PDF Download: 948