mohamady, R., zaky, M., Shenouda, H., Abd_elmonem, S. (2023). The possible protective role of melatonin and exosomes derived from Mesenchymal stem cells on cisplatin induced testicular injury in adult male albino rats: Histological and Immunohistochemical study.. Egyptian Journal of Histology, (), -. doi: 10.21608/ejh.2023.214373.1902
rania ebrahim mohamady; mohamed magdy zaky; helpies delwar Shenouda; Sahar N. Abd_elmonem. "The possible protective role of melatonin and exosomes derived from Mesenchymal stem cells on cisplatin induced testicular injury in adult male albino rats: Histological and Immunohistochemical study.". Egyptian Journal of Histology, , , 2023, -. doi: 10.21608/ejh.2023.214373.1902
mohamady, R., zaky, M., Shenouda, H., Abd_elmonem, S. (2023). 'The possible protective role of melatonin and exosomes derived from Mesenchymal stem cells on cisplatin induced testicular injury in adult male albino rats: Histological and Immunohistochemical study.', Egyptian Journal of Histology, (), pp. -. doi: 10.21608/ejh.2023.214373.1902
mohamady, R., zaky, M., Shenouda, H., Abd_elmonem, S. The possible protective role of melatonin and exosomes derived from Mesenchymal stem cells on cisplatin induced testicular injury in adult male albino rats: Histological and Immunohistochemical study.. Egyptian Journal of Histology, 2023; (): -. doi: 10.21608/ejh.2023.214373.1902
The possible protective role of melatonin and exosomes derived from Mesenchymal stem cells on cisplatin induced testicular injury in adult male albino rats: Histological and Immunohistochemical study.
Articles in Press, Accepted Manuscript, Available Online from 04 July 2023
3Department of Histology and Cell Biology faculty of Medicine - Banha University
Abstract
Abstract Overveiw: Cisplatin (CIS) is a perfect antineoplastic medicine resulting in severe testicular toxicity. Melatonin is a potent antioxidant that can prevent gonadal toxicity. exosomes have been demonstrated to have a vital effect in tissue regeneration. Aim: to evaluate the potential protective effects of melatonin and exosomes developed from bone marrow mesenchymal stem cells (BMSC-EX) in testicular toxicity caused by cisplatin. Materials and Methods: fifty rats were divided in a random way into five equal groups. Group I (control group). Group II were given a single dose (8 mg/kg) of cisplatin intraperitoneally I.P. Group III (melatonin group): intra peritoneal administration of melatonin (4 ɱg/kg) started 5 days before cisplatin injection for 15 days. Group IV (exosomes group): a single intra venous dose of 100 μց BMSC-EX one day before cisplatin dose. Group V (melatonin and exosomes). Specimens of the testicles were collected and processed for immunohistochemical and histological analysis. Results: Group II declared distortion, irregular outline of the seminiferous tubule, with critical accumulation (P